SIOPE Host Genome Working Group


A considerable percentage of childhood cancers are due to cancer predisposition syndromes (CPS) and identifying these children with CPS has significant clinical consequences for the patient and their family.

The Host Genome Working Group (HGWG) was officially launched during the first annual SIOP Europe Annual Meeting in Prague (May 2019).

This working group has the following overarching aims:

  • To study the cancer epidemiology of individuals with cancer predisposition syndromes (CPS)
  • To study the CPS biology
  • To study the genetic and environmental cancer risk modifying factors in individuals with a CPS
  • To share and grow expertise in the interpretation of cancer predisposition gene (CPG) variants
  • To improve the psychosocial support for individuals with CPS
  • To improve the diagnosis of CPS
  • To improve counselling for individuals with CPS
  • To develop cancer prevention strategies for individuals with CPS
  • To optimize cancer surveillance for individuals with CPS
  • To improve cancer treatment of patients with CPS by close collaboration with trial groups
  • To collaborate with family support organisations
  • To study the genetic component of adverse treatment reactions
  • To harmonise care standards and diagnostic procedures for individuals with CPS within Europe
  • To educate families and health professionals in host genome field
  • To study health economic aspects related to CPS


All SIOPE members can join the Host Genome Working Group by simply notifying the Chair.  To join the group, please contact the interim chair:

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