QUARTET Logo_Final

Quality and Excellence in Radiotherapy and Imaging for Children and Adolescents with Cancer across Europe in Clinical Trials

QUARTET is a radiotherapy quality assurance (RTQA) project that supports the delivery of high-quality radiotherapy for children and adolescents with cancer that are treated in clinical trials across Europe. QUARTET officially launched in 2016 and now has 16 projects in its portfolio; spanning all major tumour types affecting children and adolescents. These projects include retrospective RTQA analyses and prospective RTQA delivery as well as retrospective and prospective imaging studies. Almost 200 patients have been submitted so far.

QUARTET currently delivers centralised prospective RTQA for children and TYAs treated in prospective clinical trials for neuroblastoma (HR-NBL2, SIOPEN), rhabdomyosarcoma (FaR-RMS, EpSSG) and brain tumours (HRMB, BTG), and continues to expand as new trials are developed by the SIOPE clinical study groups.


QUARTET ensures that high standards of radiotherapy treatment are given to all patients enrolled, regardless of where they live. If you know of a trial incorporating radiotherapy and would like to find out more about integrating RTQA using QUARTET email: quartet@siope.eu.

This important project is inscribed in the wider scope of the SIOPE Strategic Plan ‘A European Cancer Plan for Children and Adolescent’, recently endorsed by the paediatric cancer community.

QUARTET is fully supported by Fondatioun Kriibskrank Kanner, Luxembourg, and delivered as a collaborative project between SIOPE and EORTC.

The Fondatioun Kriibskrank Kanner, is a Luxembourg foundation which provides multi-disciplinary support to families of children with cancer, raises awareness to improve the condition of sick children and actively supports pediatric oncology research with one goal: heal better and quicker.

Twitter: #QUARTETproject


Current Status

(Trial name - trial type - status)


How To Open A QUARTET Study? 

  • Radiotherapy Lead to contact quartet@siope.eu
  • Sponsor & CI(s) support for QUARTET involvement
  • RTQA to be delivered by QUARTET written into protocol
  • Tri-partisan contract (SIOPE-EORTC-SPONSOR)
  • Reviewer contracts (SPONSOR- Reviewers)


QUARTET Contacts